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pentobarbital will lower the extent or outcome of pioglitazone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unidentified.pentobarbital will decrease the level or impact of darifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.pentobarbital will reduce the level or impact of